Secreted autoantibody repertoires in Sjögren's syndrome and systemic lupus erythematosus: A proteomic approach

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Secreted autoantibody repertoires in Sjögren's syndrome and systemic lupus erythematosus: A proteomic approach

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作者：Mahmood A. Al Kindi^a ; Alex D. Colella^a ; ^b ; Tim K. Chataway^b ; Michael W. Jackson^a ; Jing J. Wang^a ; ¹ ; ^{jing.wang@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Tom P. Gordon^a ; ¹ ; ^{t.gordon@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：aa ; amino acid ; D ; diversity ; 2-DE ; two-dimensional gel electrophoresis ; H-chain ; heavy chain ; HCDR3 ; heavy chain complementarity determining region 3 ; HPLC ; high-performance liquid chromatography ; Ig ; immunoglobulin ; J ; joining ; L-chain ; light chain ; MRM ; multiple reactions monitoring ; MS ; mass spectrometer ; NGS ; next generation sequencing ; Q-TOF ; quadrupole-time of flight ; SLE ; systemic lupus erythematosus ; SS ; Sjö ; gren's syndrome ; V ; variable
刊名：Autoimmunity Reviews
出版年：2016
出版时间：April 2016
年：2016
卷：15
期：4
页码：405-410
全文大小：448 K

文摘

•: 2-DE/MS sequencing workflow was developed to characterise autoantibody proteomes.
•: SS/SLE V-region autoantibody signatures reveal clonal restriction/public clonotypes.
•: A combination of NGS/MS sequencing is required for complete autoantibody sequence.
•: Targeted MRM should allow novel multiplex diagnostic assays for autoimmunity.

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