The Ig V<sub>H</sub> complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor

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The Ig V_H complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor

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作者：Natalia Girola^a ; Alisson L. Matsuo^b ; Carlos R. Figueiredo^a ; Mariana H. Massaoka^a ; Camyla F. Farias^a ; Denise C. Arruda^c ; Ricardo A. Azevedo^d ; Hugo P. Monteiro^e ; Pedro T. Resende-Lara^f ; Rodrigo L.O.R. Cunha^g ; Luciano Polonelli^h ; Luiz R. Travassos^a ; ⁱ ; ^{luiztravassos@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Antitumor peptides ; Antibody CDRs ; Melanoma ; Cell migration ; Metastasis ; Hsp90 ; G-protein coupled receptor
刊名：Peptides
出版年：2016
出版时间：November 2016
年：2016
卷：85
期：Complete
页码：1-15
全文大小：4023 K

文摘

•: Rb9 is a flexible, hairpin forming, cyclic peptide, with an exposed disulfide bridge.
•: Rb9 but not the analogous linear Rb10, forms an α–helix stabilized by H-bonds.
•: Tumor cells hyperadherence and migration inhibition are cysteine-linked Rb9 effects.
•: Rb9 attenuates Hsp90 chaperone functions and activates adherence GPCR signaling.
•: Rb9 is a strong evidence of the bioactivity of isolated immunoglobulin CDR peptides.