TRPC3-mediated Ca<sup>2+</sup> entry contributes to mouse airway smooth muscle cell proliferation induced by lipopolysaccharide

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TRPC3-mediated Ca²⁺ entry contributes to mouse airway smooth muscle cell proliferation induced by lipopolysaccharide

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作者：Xiao-Xu Chen^a ; ¹ ; Jia-Hua Zhang^b ; ¹ ; Bin-Hua Pan^a ; Hui-Li Ren^a ; Xiu-Ling Feng^a ; Jia-Ling Wang^a ; Jun-Hua Xiao^a ; ^c ; ^{xiaoj@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：ACh ; acetylcholine ; AP1 ; activator protein 1 ; ASMCs ; airway smooth muscle cells ; [Ca2+]i ; intracellular free Ca2+ concentration ; COPD ; chronic obstructive pulmonary disease ; DAG ; diacylglycerol ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; ERK ; extracellular signal-regulated kinase ; FBS ; fetal bovine serum ; HBSS ; HEPES-buffered saline solution ; LPS ; lipopolysaccharide ; MAP ; mitogen-activited protein ; MTT ; methyl thiazolyl tetrazolium ; NF-κB ; nuclear factor kappaB ; NSCC ; nonselective cat
刊名：Cell Calcium
出版年：2016
出版时间：October 2016
年：2016
卷：60
期：4
页码：273-281
全文大小：1873 K

文摘

•: LPS induced airway smooth muscle cells (ASMCs) proliferation.
•: LPS enhanced TRPC3 protein expression, NSCC currents, resting and ACh-elicited [Ca²⁺]_i.
•: Blockade and gene silencing of TRPC3 inhibited LPS-induced ASMCs proliferation.
•: TRPC3-mediated Ca²⁺ entry contributes to LPS-induced ASMCs proliferation.

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