Role of the H-bond between L53 and T56 for Aquaporin-4 epitope in Neuromyelitis Optica

详细信息    查看全文

• 作者：Francesco Pisani^a ; Laura Simone^a ; ^b ; Concetta Domenica Gargano^a ; Manuela De Bellis^a ; Antonio Cibelli^a ; Maria Grazia Mola^a ; Giacomo Catacchio^a ; Antonio Frigeri^c ; ^d ; Maria Svelto^a ; ^e ; ^f ; Grazia Paola Nicchia^a ; ^d ; ^{graziapaola.nicchia@uniba.it}
• 关键词：Aquaporin-4 ; NMO ; Molecular dynamics ; OAPs ; AQP4-IgG
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1859
• 期：3
• 页码：368-376
• 全文大小：1594 K
• 卷排序：1859

文摘

The MD predicted H-bond between T56 an L53 is not involved in OAP formation and AQP4 epitope for AQP4-IgG. Protein purification procedure might affect AQP4 native architecture. MD is not suitable for defining AQP4 epitope.