Attenuated Streptococcus pneumoniae vaccine candidate SPY1 promotes dendritic cell activation and drives a Th1/Th17 response

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Attenuated Streptococcus pneumoniae vaccine candidate SPY1 promotes dendritic cell activation and drives a Th1/Th17 response

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作者：Song Gao^a ; ^b ; Lingbin Zeng^a ; ^c ; Xuemei Zhang^a ; Yingying Wu^a ; Jingjing Cui^a ; Zhixin Song^a ; Xiaoyu Sun^a ; Hong Wang^a ; Yibing Yin^a ; Wenchun Xu^a ; ^{xuwen0303@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：BMDC ; bone marrow derived dendritic cell ; DC ; dendritic cell ; APC ; antigen presentation cells ; MAPK ; mitogen activated protein kinase ; NF-κB ; Nuclear factor-kappa B ; GM-CSF ; granulocyte macrophage colony-stimulating factor ; IL-4 ; interleukin-4 ; FCM ; flow cytometry ; FcR ; Fc receptor ; MHC II ; major histocompatibility complex class II ; IFN-γ ; interferon gamma ; CFU ; colony formation unit
刊名：Immunology Letters
出版年：2016
出版时间：November 2016
年：2016
卷：179
期：Complete
页码：47-55
全文大小：2297 K

文摘

class="label">•: SPY1 induces DCs activation with high levels of pro-inflammatory cytokines and co-stimulatory molecules.
class="label">•: MAPK and NF-κB signaling pathways involved in SPY1 induced DCs activation.
class="label">•: SPY1-activated DCs induce Th1 and Th17 response in vivo and in vitro.

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