The first echinoderm poly-U-binding factor 60聽kDa (PUF60) from sea cucumber (Stichopus monotuberculatus): Molecular characterization, inducible expression and involvement of apoptosis

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The first echinoderm poly-U-binding factor 60聽kDa (PUF60) from sea cucumber (Stichopus monotuberculatus): Molecular characterization, inducible expression and involvement of apoptosis

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作者：Chunhua Ren^a ; ^b ; ^{rosemary166@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Ting Chen^a ; ^b ; ^{chan1010@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Hongyan Sun^a ; ^{hongyanlucky@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiao Jiang^a ; ^{jiangxiao4367@126.com" class="auth_mail" title="E-mail the corresponding author} ; Chaoqun Hu^a ; ^b ; ^{hucq@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Jing Qian^a ; ^{qianjing198722@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yanhong Wang^a ; ^{yhwang@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Poly-U-binding factor 60 kDa ; Stichopus monotuberculatus ; Gene structure ; Innate immune ; Apoptosis
刊名：Fish & Shellfish Immunology
出版年：2015
出版时间：November 2015
年：2015
卷：47
期：1
页码：196-204
全文大小：3303 K

文摘

class="label">•: We first identified the cDNA and gene sequences of PUF60 from a tropic sea cucumber.
class="label">•: All functional domains of PUF60 can be found in the new obtained StmPUF60.
class="label">•: StmPUF60 mRNA in coelomocytes can be inducibly expressed by immune challenge.
class="label">•: Overexpression of StmPUF60 can induce apoptosis in the HeLa cells.
class="label">•: PUF60 may play critical role in the sea cucumber innate immune defense.