Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia

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Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia

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作者：Qiong Zhang^a ; ^{joan_zhang2002@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Yinping Huang^b ; ¹ ; ^{yphuangp@126.com" class="auth_mail" title="E-mail the corresponding author} ; Keke Zhang^b ; ^{zhangkeke0806@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yanjun Huang^b ; ^{wz5000@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yan Yan^c ; ^{1019028268@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Fan Wang^a ; ^{413258460@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Jie Wu^b ; ^{wjjw307@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao Wang^b ; ^{46506149@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Zhangye Xu^a ; ^{531953862@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Yongtao Chen^c ; ^{51325023@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Xue Cheng^c ; ^{402719092@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Yong Li^d ; ^{studying@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jinyu Jiao^c ; ^{402591446@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Duyun Ye^c ; ^{yedy@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Preeclampsia ; Cadmium ; Angiotensin II type 1 receptor agonistic autoantibody ; Activation-induced cytosine deaminase ; Complement
刊名：Environmental Pollution
出版年：2016
出版时间：November 2016
年：2016
卷：218
期：Complete
页码：770-782
全文大小：3919 K

文摘

class="label">•: The cadmium levels in the peripheral blood of preeclamptic patients were higher than those in normal pregnancy.
class="label">•: A novel rat model of preeclampsia by injection with low-dose CdCl2 during GD 9-14 was established.
class="label">•: Cadmium increased AT1-AA level by upregulating activation-induced cytosine deaminase in B cells.
class="label">•: AT1-AA-mediated AT1 receptor activation is responsible for C5 elevation.
class="label">•: Elevated C5a contributes to key features of PE seen in the CdCl2-injection model.