Inhibition of c-Src activity improves metabolic parameters and prevents renal cell apoptosis in diabetic db/db mice.

Inhibition of c-Src activity inhibits phosphorylation of c-Src and p38 MAPK in the kidneys of diabetic db/db mice.

Inhibition of c-Src activity prevents HG-induced c-Src and p38 MAPK activation in HK-2 cells.

Inhibition of p38 MAPK activity prevents HG-induced c-Src activation and expression of PPARγ and CHOP in HK-2 cells.

Inhibition of c-Src or p38 MAPK activity prevents HG-induced apoptosis of HK-2 cells.