Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells

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Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells

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作者：Long-Xing Xue^a ; Zhong-Hang Xu^b ; Jiao-Qi Wang^a ; Yang Cui^a ; Hong-Yu Liu^a ; Wen-Zhao Liang^a ; Qiu-Ye Ji^c ; Jin-Ting He^a ; Yan-Kun Shao^a ; Jing Mang^a ; ^{mangjing@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhong-Xin Xu^a ; ^{xuzhongxin999@aliyun.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Activin A/Smads ; Autophagy ; JNK ; p38 ; Oxygen Glucose Deprivation (OGD)
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：18 November 2016
年：2016
卷：480
期：3
页码：355-361
全文大小：1287 K

文摘

class="label">•: Autophagy activation is increasing with the prolongation of Oxygen Glucose Deprivation (OGD) in neuronal PC12 cells.
class="label">•: JNK and p38 MAPK pathways are involved in the OGD-induced autophagy in neuronal PC12 cells.
class="label">•: Act A/Smads signaling pathway inhibits the activation of JNK/p38 cascades, and thereby negatively regulating the autophagy in OGD-treated PC12 cells.