5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells

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5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells

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作者：Julia Senkiv^a ; Nataliya Finiuk^a ; Danylo Kaminskyy^b ; Dmytro Havrylyuk^b ; Magdalena Wojtyra^b ; Iryna Kril^b ; Andrzej Gzella^c ; Rostyslav Stoika^a ; Roman Lesyk^b ; ^{dr_r_lesyk@org.lviv.net" class="auth_mail" title="E-mail the corresponding author} ; ^{dr_lesyk@meduniv.lviv.ua" class="auth_mail" title="E-mail the corresponding author}
关键词：5-Ene-4-thiazolidinones ; Anticancer activity ; Leukemia ; Apoptosis ; ROS
刊名：European Journal of Medicinal Chemistry
出版年：2016
出版时间：19 July 2016
年：2016
卷：117
期：Complete
页码：33-46
全文大小：1396 K

文摘

class="label">•: New 5-enamine-4-thiazolidinones with selective antileukemic action.
class="label">•: Mitochondria-depended apoptosis was identified as the main mode of action.
class="label">•: Compound class="boldFont">1 induces G₀/G₁ arrest and activation of ROS production.
class="label">•: Compound class="boldFont">1 possesses low toxicity towards pseudonormal cells.

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