Peptide fragment of thymosin β4 increases hippocampal neurogenesis and facilitates spatial memory

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Peptide fragment of thymosin β4 increases hippocampal neurogenesis and facilitates spatial memory

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作者：D.H. Kim^a ; ^b ; ^&dagger ; ; E.-Y. Moon^c ; ^&dagger ; ; ^{eunyimoon@sejong.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; J.H. Yi^d ; H.E. Lee^e ; ^g ; S.J. Park^e ; ^g ; Y.-K. Ryu^c ; H.-C. Kim^h ; S. Leeⁱ ; J.H. Ryu^e ; ^f ; ^g ; ^{jhryu63@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：Ac-SDKP ; N-acetyl-serylaspartyl-lysyl-proline ; ANOVA ; one-way analysis of variance ; BrdU ; 5-bromo-2&prime ; -deoxyuridine ; DCX ; doublecortin ; DG ; dentate gyrus ; GFAP ; glial fibrillary acidic protein ; GSK-3β ; glycogen synthase kinase-3β ; NeuN ; neuronal nuclei ; NPCs ; neural progenitor cells ; PBS ; phosphate-buffered saline ; TB4 ; thymosin β4
刊名：Neuroscience
出版年：2015
出版时间：3 December 2015
年：2015
卷：310
期：Complete
页码：51-62
全文大小：1673 K

文摘

class="label">•: N-acetyl-serylaspartyl-lysyl-proline (Ac-SDKP), a peptide fragment of thymosin β4 facilitated hippocampal neurogenesis.
class="label">•: Ac-SDKP increase in β-catenin stability with reduction of glycogen synthase kinase-3β activity.
class="label">•: Moreover, inhibition of VEGF signaling blocked Ac-SDKP-facilitated neural proliferation.
class="label">•: Subchronic intrahippocampal infusion of Ac-SDKP also increased spatial memory.
class="label">•: Taken together, these data demonstrate that TB4 functions as a regulator of neurogenesis.

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