Early immature neuronal death is partially involved in memory impairment induced by cerebral ischemia

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Early immature neuronal death is partially involved in memory impairment induced by cerebral ischemia

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作者：Jee Hyun Yi^a ; So Yeon Cho^d ; Se Jin Jeon^e ; ^g ; Ji Wook Jung^h ; Man Seok Parkⁱ ; Dong Hyun Kim^b ; ^c ; ^{mose79@dau.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Jong Hoon Ryu^e ; ^f ; ^g ; ^{jhryu63@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：Ischemia ; Immature neuron ; Spatial memory ; Long-term potentiation
刊名：Behavioural Brain Research
出版年：2016
出版时间：15 July 2016
年：2016
卷：308
期：Complete
页码：75-82
全文大小：1824 K

文摘

class="label">•: We found early immature neuronal death, which was determined by DCX and NeuN-double-staining.
class="label">•: Injection of caspase-3 inhibitor rescued cells from immature neuronal death.
class="label">•: z-DEVD-fmk treatment partially rescued ischemia-induced spatial memory impairment.
class="label">•: Ischemia-induced LTP impairment in the perforant pathway was restored by z-DEVD-fmk treatment.

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