Enantiomeric pair of copper(II) polypyridyl-alanine complexes: Effect of chirality on their interaction with biomolecules

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Enantiomeric pair of copper(II) polypyridyl-alanine complexes: Effect of chirality on their interaction with biomolecules

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作者：Chew Hee Ng^a ; ^{NgChewHee@imu.edu.my" class="auth_mail" title="E-mail the corresponding author} ; Cheang Wei Chan^a ; ^c ; ^{estichan91@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jing Wei Lai^a ; ^{janice_ljw_92@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Ing Hong Ooi^a ; ^{inghong_ooi@imu.edu.my" class="auth_mail" title="E-mail the corresponding author} ; Kok Vei Chong^b ; ^{Destiny.chong.james@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mohd Jamil Maah^c ; ^{mjamil@um.edu.my" class="auth_mail" title="E-mail the corresponding author} ; Hoi Ling Seng^d ; ^{hoilings@sunway.edu.my" class="auth_mail" title="E-mail the corresponding author}
关键词：Ternary copper(II) complexes ; Chirality ; Deoxyribonucleic acid ; Restriction enzyme ; Topoisomerase I ; Proteasome
刊名：Journal of Inorganic Biochemistry
出版年：2016
出版时间：July 2016
年：2016
卷：160
期：Complete
页码：1-11
全文大小：1154 K

文摘

class="label">•: Each [Cu(phen)(ala)(H₂O)]⁺ (phen = phenanthroline; ala = alanine) is square pyramidal.
class="label">•: Chirality of ala has no effect on production of hydroxyl radicals by all enantiomers.
class="label">•: No or minimum effect of chirality on interaction with proteasome and most forms of DNA.
class="label">•: Chirality of ala affects restriction enzyme inhibition, binding to albumin and ds(AT)₆.
class="label">•: Complexes exhibit selective inhibition of the proteasome trypsin-like site.

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