Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

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Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

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作者：Mahsa Hassanipour^a ; ^b ; ^c ; ¹ ; ^{mhasanipoor@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hossein Amini-Khoei^a ; ^d ; ¹ ; ^{aminikhoyi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hamed Shafaroodi^e ; ^{hshafaroodi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Armin Shirzadian^a ; ^b ; ^{armin_shirzadian@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Nastaran Rahimi^a ; ^b ; ^{nastaran.rahimee@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Muhammad Imran-Khan^a ; ^b ; ^{muhammad_ik12@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Seyed-Mahdi Rezayat^b ; ^e ; ^{rezayat1387@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ahmadreza Dehpour^a ; ^b ; ^{Dehpour@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
关键词：Atorvastatin ; Morphine ; Antinociception ; Tolerance ; Nitric oxide ; Mice
刊名：Brain Research Bulletin
出版年：2016
出版时间：July 2016
年：2016
卷：125
期：Complete
页码：173-180
全文大小：1456 K

文摘

class="label">•: Atorvastatin reversed the development phase of morphine analgesic tolerance.
class="label">•: Atorvastatin mitigated the expression phase of analgesic tolerance to morphine.
class="label">•: Nitrergic system was involved in the effects of atorvastatin.

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