Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb.

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Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb.

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作者：Min Wang¹ ; Xiao-bo Yang¹ ; Jing-wen Zhao ; Chuan-jian Lu ; ^{luchuanjian888@vip.sina.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Zhu ; ^{zhuwei160409@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; ^{zhuwei9201@163.com" class="auth_mail" title="E-mail the corresponding author} ;
关键词：Smilax glabra Roxb. ; Polysaccharide ; Structure ; Immunomodulatory activity ; NLRP3 inflammasome
刊名：Carbohydrate Polymers
出版年：2017
出版时间：20 January 2017
年：2017
卷：156
期：Complete
页码：390-402
全文大小：2796 K

文摘

class="label">•: A novel heteropolysaccharide (SGRP1) with notable immunomudulatory activity is obtained from Smilax glabra Roxb.
class="label">•: Structure of SGRP1 is characterized by HPGPC, GC, GC–MS, FT-IR and NMR.
class="label">•: Immunomodulatory effects of SGRP1 are evaluated with RAW264.7 cells.
class="label">•: SGRP1 promote the phagocytosis and increase the secretion of NO, IL-6, TNF-α and IL-1β.
class="label">•: The immunomodularoty mechanism of SGRP1 is elucidated for the first time.

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