WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation

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WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation

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作者：Tamara Ouspenskaia¹ ; Irina Matos¹ ; Aaron F. Mertz¹ ; Vincent F. Fiore¹ ; Elaine Fuchs¹ ; ^{fuchslb@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell
出版年：2016
出版时间：14 January 2016
年：2016
卷：164
期：1-2
页码：156-169
全文大小：6376 K

文摘

class="label">•: Asymmetric divisions within hair buds differentially partition WNT and SHH signaling
class="label">•: This partitioning couples asymmetric cell division to asymmetric cell fate
class="label">•: WNT^lo daughters that respond to, but do not produce, SHH expand symmetrically
class="label">•: WNT^hi SHH-producing cells ultimately cease producing stem cell daughters

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