Optic neuritis (ON) in MS is younger-onset, shorter, and shows a better outcome.
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ON with serum anti-AQP4-Ab is female-dominant, older-onset, and shows a worse outcome.
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ON with serum anti-MOG-Ab is longer with swelling, but shows a better outcome.
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Idiopathic ON is much rarer compared to the three demyelinating diseases.
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Cerebral MRI and serum autoantibodies should be studied to make a correct diagnosis.
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