Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

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Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

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作者：Ana C. Queiró ; s¹ ; ¹⁹ ; René ; e Beekman² ; ¹⁹ ; Roser Vilarrasa-Blasi¹ ; ¹⁹ ; Martí ; Duran-Ferrer¹ ; Guillem Clot² ; Angelika Merkel³ ; Emanuele Raineri³ ; Nuria Russiñ ; ol¹ ; ² ; Giancarlo Castellano² ; Sí ; lvia Beà ; ² ; Alba Navarro² ; Marta Kulis¹ ; Nú ; ria Verdaguer-Dot¹ ; ² ; Pedro Jares¹ ; ⁴ ; Anna Enjuanes⁴ ; Marí ; a José ; Calasanz⁵ ; Anke Bergmann⁶ ; ⁷ ; Inga Vater⁶ ; Itziar Salaverrí ; a² ; Harmen J.G. van de Werken⁸ ; ⁹ ; ¹⁰ ; Wyndham H. Wilson¹¹ ; Avik Datta¹² ; Paul Flicek¹² ; Romina Royo¹³ ; Joost Martens¹⁴ ; Eva Giné ; ¹⁵ ; Armando Lopez-Guillermo¹⁵ ; Hendrik G. Stunnenberg¹⁴ ; Wolfram Klapper¹⁶ ; Christiane Pott¹⁷ ; Simon Heath³ ; Ivo G. Gut³ ; Reiner Siebert⁶ ; Elí ; as Campo¹ ; ² ; ¹⁸ ; José ; I. Martí ; n-Subero¹ ; ² ; ²⁰ ; ^{imartins@clinic.ub.es" class="auth_mail" title="E-mail the corresponding author}
关键词：epigenomics ; DNA methylation ; lymphoma ; mantle cell lymphoma ; DNA looping ; SOX11 ; enhancer ; ChIP-seq ; chromatin ; whole-genome bisulfite sequencing
刊名：Cancer Cell
出版年：2016
出版时间：14 November 2016
年：2016
卷：30
期：5
页码：806-821
全文大小：8149 K

文摘

class="label">•: Epigenetic imprints of normal B cell subpopulations identify two subtypes of MCL
class="label">•: Dynamically methylated regions in normal B cells acquire additional changes in MCL
class="label">•: Identification of distant enhancers of oncogenes as potential epigenetic drivers
class="label">•: Epigenetic heterogeneity in MCL is linked to genetic changes and clinical behavior

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