Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols

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Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols

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作者：Fá ; bio de Souza Fernandes^a ; Tayrine Silva Fernandes^a ; Lí ; gia Souza da Silveira^a ; Wiliam Caneschi^a ; Maria Cristina S. Lourenç ; o^b ; Claudio G. Diniz^c ; Pollyanna Francielli de Oliveira^d ; Sabrina de Paula Lima Martins^d ; Daiane Eleuté ; rio Pereira^d ; Denise Crispim Tavares^d ; Mireille Le Hyaric^a ; Mauro V. de Almeida^a ; Mara Rubia C. Couri^a ; ^{mara.rubia@ufjf.edu.br" class="auth_mail" title="E-mail the corresponding author}
关键词：galactopyranosylated amino alcohols ; antibacterial ; antitumor ; lipophilicity
刊名：European Journal of Medicinal Chemistry
出版年：2016
出版时间：27 January 2016
年：2016
卷：108
期：Complete
页码：203-210
全文大小：441 K

文摘

class="label">•: A series of fifteen new galactopyranosylated amino alcohols were synthesized.
class="label">•: The compounds were evaluated against Mycobacterium tuberculosis and Gram positive and negative bacteria.
class="label">•: Two amino alcohols were active against S. epidermidis (MIC = 2 μg/mL).
class="label">•: Antitumor activity was evaluated against three tumor cell lines.
class="label">•: Compound class="boldFont">16 showed the lowest IC₅₀ against MCF-7 (11.9 μM) and MO59J (10.0 μM).

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