Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

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Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

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作者：Sabine Hellwig^a ; ^{sabine.hellwig@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author} ; Simone Brioschi^a ; Sandra Dieni^a ; Lars Frings^b ; ^c ; Annette Masuch^a ; Thomas Blank^d ; Knut Biber^a ; ^e ; ^{knut.biber@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Depression ; Fractalkine ; CX3CR1 ; CX3CL1 ; Stress ; Microglia
刊名：Brain, Behavior, and Immunity
出版年：2016
出版时间：July 2016
年：2016
卷：55
期：Complete
页码：126-137
全文大小：3448 K

文摘

class="label">•: CX3CR1-deficient mice are resistant to chronic stress in the CDM model.
class="label">•: Microglia in wild type animals show hyper-ramification in the CDM model.
class="label">•: Microglia hyper-ramification may be crucial for depressive-like behavior development.

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