Ranibizumab interacts with the VEGF-A/VEGFR-2 signaling pathway in human RPE cells at different levels

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Ranibizumab interacts with the VEGF-A/VEGFR-2 signaling pathway in human RPE cells at different levels

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作者：Mahdy Ranjbar^a ; ^b ; ^{eye.research101@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Max Philipp Brinkmann^a ; ^b ; ^{maxphilipp.brinkmann@uksh.de" class="auth_mail" title="E-mail the corresponding author} ; Aysegü ; l Tura^a ; ^{ayseguel.tura@uksh.de" class="auth_mail" title="E-mail the corresponding author} ; Martin Rudolf^a ; ^{mirudolf@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Yoko Miura^a ; ^c ; ¹ ; ^{miura@bmo.uni-luebeck.de" class="auth_mail" title="E-mail the corresponding author} ; Salvatore Grisanti^a ; ¹ ; ^{salvatore.grisanti@uksh.de" class="auth_mail" title="E-mail the corresponding author}
关键词：VEGF-A ; vascular endothelial growth factor A ; VEGFR-2 ; vascular endothelial growth factor receptor 2 ; RPE ; retinal pigment epithelium ; AMD ; age-related macular degeneration
刊名：Cytokine
出版年：2016
出版时间：July 2016
年：2016
卷：83
期：Complete
页码：210-216
全文大小：1146 K

文摘

class="label">•: Ranibizumab is taken up into RPE cells and accumulates within the cells.
class="label">•: VEGFR-2 is involved in the uptake mechanism of ranibizumab.
class="label">•: Ranibizumab affects VEGF-A metabolism through extra- and intracellular pathways.
class="label">•: Oxidative stress inhibits RPE cell proliferation.
class="label">•: Ranibizumab enhances the anti-proliferative effect of oxidative stress.

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