Association of vaccine handling conditions with effectiveness of live attenuated influenza vaccine against H1N1pdm09 viruses in the United States

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Association of vaccine handling conditions with effectiveness of live attenuated influenza vaccine against H1N1pdm09 viruses in the United States

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作者：Herve Caspard ; ^{caspardh@medimmune.com" class="auth_mail" title="E-mail the corresponding author} ; Kathleen L. Coelingh¹ ; ^{kcoelingh@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Raburn M. Mallory ^{malloryr@medimmune.com" class="auth_mail" title="E-mail the corresponding author} ; Christopher S. Ambrose ^{ambrosec@medimmune.com" class="auth_mail" title="E-mail the corresponding author}
关键词：CDC ; US Centers for Disease Control and Prevention ; E47 ; glutamic residue at position 47 ; IIV ; inactivated influenza vaccine ; LAIV ; live attenuated influenza vaccine ; SPSN ; Sentinel Provider Surveillance Network ; TNCC ; test-negative case control ; US ; United States ; VE ; vaccine effectiveness
刊名：Vaccine
出版年：2016
出版时间：30 September 2016
年：2016
卷：34
期：42
页码：5066-5072
全文大小：850 K

文摘

class="label">•: In 2013–2014, LAIV was effective against influenza B but not A/H1N1pdm09 in the US.
class="label">•: Lot shipping date and outdoor temperature were associated with VE against A/H1N1.
class="label">•: New analyses showed no significant LAIV VE against H1N1pdm09 in 2010–2011 in the US.
class="label">•: From 2010 to 2014, moderate to high VE for LAIV was observed against A/H3N2 and B.
class="label">•: A more heat-stable A/H1N1pdm09 LAIV strain was manufactured for 2015–2016.

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