Prime-boost therapeutic vaccination in mice with DNA/DNA or DNA/Fowlpox virus recombinants expressing the Human Papilloma Virus type 16 E6 and E7 mutated proteins fused to the coat protein of Potato virus X

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作者：Elena Illiano^a ; ¹ ; ^{elena.illiano@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Massimiliano Bissa^a ; ¹ ; ³ ; ^{massimiliano.bissa@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; ^{massimiliano.bissa@nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Francesca Paolini^b ; ^{francesca.paolini@ifo.gov.it" class="auth_mail" title="E-mail the corresponding author} ; Carlo Zanotto^c ; ^{carlo.zanotto@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Carlo De Giuli Morghen^d ; ^e ; ^{carlo.degiulimorghen@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Rosella Franconi^f ; ^{rosella.franconi@enea.it" class="auth_mail" title="E-mail the corresponding author} ; Antonia Radaelli^a ; ^d ; ² ; ^{antonia.radaelli@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Aldo Venuti^b ; ² ; ^{aldo.venuti@ifo.gov.it" class="auth_mail" title="E-mail the corresponding author}
关键词：HPV therapeutic vaccines ; Fowlpox virus recombinants ; Prime/boost immunizations ; Potato virus X coat protein ; E6 and E7 modified oncoproteins
刊名：Virus Research
出版年：2016
出版时间：2 October 2016
年：2016
卷：225
期：Complete
页码：82-90
全文大小：1131 K

文摘

class="label">•: FP-E6_F47RCP and FP-E7_GGGCP correctly express transgenes in different cell lines.
class="label">•: After the genetic immunization, tumor volume was lower than in the control mice.
class="label">•: Genetic immunization delayed tumor appearance compared to control mice.
class="label">•: After DNA/FP vaccination, better results were obtained by E6/E7 single immunogens.