Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity

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Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity

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作者：Sartaj Tabassum^a ; ^{tsartaj62@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Musheer Ahmad^b ; Mohd Afzal^a ; Mehvash Zaki^a ; Md. Serajul Haque Faizi^c ; Akram Ali^c
关键词：UV&ndash ; vis ; UV&ndash ; visible ; CT DNA ; calf thymus DNA ; Tris ; tris(hydroxymethyl)aminomethane ; EB ; ethidium bromide ; HSA ; human serum albumin
刊名：Inorganica Chimica Acta
出版年：2016
出版时间：1 September 2016
年：2016
卷：451
期：Complete
页码：216-226
全文大小：3945 K

文摘

class="label">•: New Co(II)-based complex was synthesized and characterized.
class="label">•: In vitro DNA binding studies revealed the electrostatic mode of binding.
class="label">•: Complex class="boldFont">1 shows efficient pBR322 DNA cleavage induced by ROS.
class="label">•: Complex class="boldFont">1 recognizes minor groove.