BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis

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BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis

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作者：Sharad Verma^a ; ¹ ; ^{sharadbt215@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sukriti Goyal^b ; ¹ ; ^{sukriti1610@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chetna Tyagi^a ; ^{cheta231@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Salma Jamal^b ; ^{salmaangel30@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Aditi Singh^c ; ^{aditi225@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Abhinav Grover^a ; ^{abhinavgr@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{agrover@jnu.ac.in" class="auth_mail" title="E-mail the corresponding author}
关键词：BAX ; BCL-2-associated X protein ; BIM ; BCL-2 interacting mediator of cell death ; DEER ; Double electron electron resonance ; MD ; Molecular dynamics ; PCA ; Principal component analysis ; RMSD ; Root mean square deviation ; RMSF ; Root mean square fluctuation ; SAHB ; stabilized α helix of BCL2 ; SASA ; Solvent accessible surface area
刊名：Journal of Molecular Graphics and Modelling
出版年：2016
出版时间：June 2016
年：2016
卷：67
期：Complete
页码：94-101
全文大小：3272 K

文摘

class="label">•: Provides molecular insights into the in-active BAX-BIM SAHB complex.
class="label">•: Conformational events occurred in N terminal, BH3 domain and helix 9.
class="label">•: Reveals that BIM SAHB forms a stable complex with BAX but remains in a non-functional conformation.

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