Growth factor expression mediates resistance to EGFR inhibitors in head and neck squamous cell carcinomas

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Growth factor expression mediates resistance to EGFR inhibitors in head and neck squamous cell carcinomas

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作者：Susanne R. Tepper^a ; ^b ; ^{susanne@seiwertlab.com" class="auth_mail" title="E-mail the corresponding author} ; Zhixiang Zuo^a ; ^{zhixiang@seiwertlab.com" class="auth_mail" title="E-mail the corresponding author} ; Arun Khattri^a ; ^{arun@seiwertlab.com" class="auth_mail" title="E-mail the corresponding author} ; Jochen Heß ; ^b ; ^c ; ^{j.hess@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Tanguy Y. Seiwert^a ; ^{tseiwert@medicine.bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：EGFR ; epidermal growth factor receptor ; HNSCC ; head and neck squamous cell carcinoma ; RTK ; receptor tyrosine kinase ; CAFs ; cancer associated fibroblasts
刊名：Oral Oncology
出版年：2016
出版时间：May 2016
年：2016
卷：56
期：Complete
页码：62-70
全文大小：1711 K

文摘

class="label">•: Gefitinib treatment reduces viability in HN5, HN13, SCC61 and H400 HNSCC cell lines.
class="label">•: AREG, HGF, TGFβ1, IGF1, FGF1 or FGF2 impair response of tumor cells to gefitinib.
class="label">•: Gefitinib induces and growth factors diminish basal apoptosis in HNSCC tumor cells.
class="label">•: Growth factor (GF) combinations have higher impact on viability than single GFs.
class="label">•: Receptor expression indicates the extent of accordant ligands’ effect on viability.

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