Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin

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Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin

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作者：Jean-Charles Gautier^a ; ¹ ; ^{jean-charles.gautier@sanofi.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaobing Zhou^b ; ¹ ; Yi Yang^c ; Thierry Gury^a ; Zhe Qu^b ; Xavier Palazzi^a ; Jean-Franç ; ois Lé ; onard^a ; Mohamed Slaoui^a ; Yaligara Veeranagouda^a ; Isabelle Guizon^a ; Eric Boitier^a ; Aziz Filali-Ansary^a ; Bart H.J. van den Berg^d ; Oliver Poetz^d ; Thomas Joos^d ; Tianyi Zhang^e ; Jufeng Wang^b ; Philippe Detilleux^a ; Bo Li^b ; ^{libo@nifdc.org.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：AKI ; acute kidney injury ; BUN ; blood urea nitrogen ; DIKI ; drug induced kidney injury ; EIA ; enzyme immunoassay ; EMA ; European Medicines Agency ; FDA ; US Food and Drug Administration ; FNIH ; Foundation for the National Institutes of Health ; HESI ; Health and Environmental Sciences Institute ; IHC ; immunohistochemistry ; IMI SAFE-T ; Innovative Medicines Initiative-Safer and Faster Evidence-based Translation ; IP-LC/MS ; immunoprecipitation-liquid chromatography/mass spectrometry ; Kim-1 ; kidney injury mole
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 July 2016
年：2016
卷：303
期：Complete
页码：1-10
全文大小：1427 K

文摘

class="label">•: Gentamicin induced kidney tubular cell degeneration/necrosis in Cynomolgus monkey
class="label">•: Urinary clusterin and osteopontin were sensitive biomarkers of kidney injury.
class="label">•: Microalbumin and α1-microglobulin in urine were also more sensitive than serum creatinine.

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