Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

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Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

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作者：Jocelyn P. Wong¹ ; ⁶ ; Jason R. Todd¹ ; ⁶ ; Martina A. Finetti² ; Frank McCarthy¹ ; Malgorzata Broncel¹ ; Simon Vyse¹ ; Maciej T. Luczynski¹ ; Stephen Crosier² ; Karen A. Ryall³ ; Kate Holmes¹ ; Leo S. Payne¹ ; Frances Daley⁴ ; Patty Wai⁴ ; Andrew Jenks⁵ ; Barbara Tanos⁵ ; Aik-Choon Tan³ ; Rachael C. Natrajan⁴ ; Daniel Williamson² ; Paul H. Huang¹ ; ⁷ ; ^{paul.huang@icr.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：signal transduction ; receptor tyrosine kinase ; rhabdoid tumor ; tyrosine kinase inhibitor ; SWI/SNF ; SMARCB1 ; PDGFRα ; FGFR1 ; pazopanib
刊名：Cell Reports
出版年：2016
出版时间：25 October 2016
年：2016
卷：17
期：5
页码：1265-1275
全文大小：4340 K

文摘

•: Malignant rhabdoid tumors display coactivation of PDGFRα and FGFR1
•: Dual inhibition of PDGFRα and FGFR1 leads to synergistic apoptosis
•: FGFR1 inhibition overcomes acquired resistance to pazopanib treatment
•: PDGFRα and FGFR1 are expressed in rhabdoid tumor patient specimens

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