Enzyme and metabolic engineering for the production of novel biopolymers: crossover of biological and chemical processes

详细信息    查看全文

• 作者：Ken鈥檌chiro Matsumoto ; Seiichi Taguchi
• 刊名：Current Opinion in Biotechnology
• 出版年：December, 2013
• 年：2013
• 卷：24
• 期：6
• 页码：1054-1060
• 全文大小：565 K

文摘

The development of synthetic biology has transformed microbes into useful factories for producing valuable polymers and/or their precursors from renewable biomass. Recent progress at the interface of chemistry and biology has enabled the production of a variety of new biopolymers with properties that substantially differ from their petroleum-derived counterparts. This review touches on recent trials and achievements in the field of biopolymer synthesis, including chemo-enzymatically synthesized aliphatic polyesters, wholly biosynthesized lactate-based polyesters, polyhydroxyalkanoates and other unusual bacterially synthesized polyesters. The expanding diversities in structure and the material properties of biopolymers are key for exploring practical applications. The enzyme and metabolic engineering approaches toward this goal are discussed by shedding light on the successful case studies.