Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats

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• 关键词：C1q/TNF-related protein 6 ; Adipocytokine ; Hypertension ; Vascular endothelial dysfunction ; Angiotensin II ; PPARγ activation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：727-734
• 全文大小：1762 K
• 卷排序：482

文摘

Serum CTRP6 was significantly decreased in spontaneously hypertensive rats (SHRs). CTRP6 positively regulated the activation of the ERK1/2 signaling pathway. CTRP6 negatively regulates PPARγ mediated Angiotensin II (AngII) expression. CTRP6 alleviates AngII-induced hypertension and vascular endothelial dysfunction.