Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

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• 作者：Jesmond Dalli¹ ; ² ; ^{j.dalli@qmul.ac.uk} ; Romain A. Colas¹ ; ² ; Hildur Arnardottir¹ ; ³ ; Charles N. Serhan¹ ; ⁴ ; ^{cnserhan@zeus.bwh.harvard.edu}
• 关键词：protectins ; infections ; macrophages ; inflammation ; omega-3 ; vagal reflex ; lipid mediator profiling
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：92-105
• 全文大小：2598 K
• 卷排序：46

文摘

Vagotomy reduces tissue PCTR1 amounts and ILC3 numbers, delaying infection resolution ILC3 depletion alters peritoneal macrophage phenotype and reduces peritoneal PCTR1 Acetylcholine upregulates the PCTR pathway in mouse and human ILC3s ILC3 or PCTR1 restores peritoneal macrophage responses and resolution of infections