Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway

详细信息查看全文

作者：Yan-Ling Wu^a ; ¹ ; Yu-Jing Zhang^a ; ¹ ; You-Li Yao^a ; Zhi-Man Li^a ; Xin Han^a ; Li-Hua Lian^a ; Yu-Qing Zhao^b ; Ji-Xing Nan^a ; ^c ; ^{jxnan@ybu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：CuE ; Cucurbitacin E ; ECM ; extracellular matrix ; HSCs ; Hepatic stellate cells ; TNF-α ; tumor necrosis factor-α ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; PARP ; poly ADP-ribose polymerase ; MAPK ; mitogen activated protein kinase ; ERK ; extracellular signal regulated kinase ; JNK ; c-Jun N-terminal kinase ; TAA ; thioacetamide ; Cur ; curcumin group ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; α-SMA ; alpha-smooth - muscle actin ; TIMP-1 ; tissue inhibitor of metall
刊名：Toxicology Letters
出版年：2016
出版时间：6 September 2016
年：2016
卷：258
期：Complete
页码：147-158
全文大小：4995 K

文摘

el">•: Cucurbitacin E induces apoptosis and attenuates activation of hepatic stellate cells.
el">•: Cucurbitacin E alleviated thioacetamide-induced hepatic fibrosis.
el">•: Cucurbitacin E regulates Akt-AMPK-mTOR signaling pathway.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.