The 5-HT_1A receptor in Major Depressive Disorder

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• 作者：Joshua Kaufman ; ^{Joshua.Kaufman@stonybrookmedicine.edu" class="auth_mail" title="E-mail the corresponding author} ; Christine DeLorenzo ; Sunia Choudhury ; Ramin V. Parsey
• 关键词：5-HT1A ; Depression ; Review
• 刊名：European Neuropsychopharmacology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：26
• 期：3
• 页码：397-410
• 全文大小：1239 K

文摘

Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030. A large body of previous research has theorized that serotonergic dysfunction, specifically of the serotonin (5-HT) 1A receptor, plays a key role in the development of MDD. The purpose of this review is to describe the evolution of our current understanding of the serotonin 1A (5-HT_1A) receptor and its role in the pathophysiology MDD through the discussion of animal, post-mortem, positron emission tomography (PET), pharmacologic and genetic studies.