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• 作者：Allister Vale
• 关键词：Dicobalt edetate ; hydroxocobalamin ; oxygen ; sodium nitrite ; sodium thiosulfate
• 刊名：Medicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：44
• 期：3
• 页码：157
• 全文大小：50 K

文摘

Cyanide reversibly inhibits cytochrome oxidase a_3. Severe poisoning is characterized by coma, convulsions, cerebral oedema, pulmonary oedema, cardiovascular collapse, cardiac conduction defects, arrhythmias and metabolic acidosis. In addition to oxygen, either dicobalt edetate or hydroxocobalamin should be administered intravenously. If these antidotes are not available, sodium nitrite and sodium thiosulfate should be given.