Cytotoxic cyclolignans related to podophyllotoxin

详细信息    查看全文

• 作者：Gordaliza ; Marina ; Miguel del Corral ; José ; M. ; Angeles Castro ; M. ; Garcí ; a-Garcí ; a ; Pablo A. ; et. al.
• 关键词：Cyclolignans ; Podophyllotoxin ; Pyrazoline ; Cytotoxic ; Antineoplastic ; Immunosuppressive
• 刊名：Il Farmaco
• 出版年：2001
• 出版时间：April 1, 2001
• 年：2001
• 卷：56
• 期：4
• 页码：297-304
• 全文大小：141 K

文摘

The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of cancer chemotherapy protocols. Due to these biological activities, cyclolignans have been the objective of numerous studies focused to prepare better and safer anticancer drugs. Several cyclolignans related to podophyllotoxin have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28); some of them have antiviral and immunosuppressive activities.