Germline ablation of dermatan-4O-sulfotransferase1 reduces regeneration after mouse spinal cord injury

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Germline ablation of dermatan-4O-sulfotransferase1 reduces regeneration after mouse spinal cord injury

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作者：S. Rost^a ; ^&dagger ; ; N. Akyü ; z^a ; ^&dagger ; ; T. Martinovic^a ; ^b ; T. Huckhagel^a ; I. Jakovcevski^a ; ^c ; ^d ; ^{igor.jakovcevski@dzne.de" class="auth_mail" title="E-mail the corresponding author} ; M. Schachner^a ; ^e ; ^f ; ^{schachner@stu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：ChABC ; chondroitinase ABC ; ChAC ; chondroitinase AC ; ChAT ; choline acetyltransferase ; ChB ; chondroitinase B ; Chst14 ; carbohydrate sulfotransferase 14 also known as dermatan-4O-sulfotransferase1 ; CS ; chondroitin sulfate ; CSPG ; chondroitin sulfate proteoglycan ; DS ; dermatan sulfate ; DSPG ; dermatan sulfate proteoglycan ; GFAP ; glial fibrillary acidic protein ; NG2 ; new glue 2 also known as chondroitin sulfate proteoglycan 4 (CSPG4) ; MBP ; myelin basic protein ; SCI ; spinal cord injury ; TH ; tyrosine hydr
刊名：Neuroscience
出版年：2016
出版时间：15 January 2016
年：2016
卷：312
期：Complete
页码：74-85
全文大小：3285 K

文摘

•: We developed mice deficient in Chst14, pivotal enzyme by generation of dermatan sulfate.
•: We performed spinal cord injury in Chst14-deficient mice (Chst14^−/−).
•: We observed reduced locomotor recovery after spinal cord injury in Chst14^−/− versus Chst14^+/+ mice.
•: Chst14 ablation slightly reduced axonal regeneration, and had no effect on glial scar formation.

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