Alkoxyamino glycoside acceptors for the regioselective synthesis of oligosaccharides using glycosynthases and transglycosidases

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• 作者：David Teze ; Michel Dion ; Franck Daligault ; Vinh Tran ; Corinne André ; -Miral ; ^{corinne.miral@univ-nantes.fr} ; Charles Tellier
• 关键词：Transglycosidases ; Glycosynthases ; Oligosaccharide synthesis ; Alkoxyaminoglucoside ; Regioselectivity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：15 January, 2013
• 年：2013
• 卷：23
• 期：2
• 页码：448-451
• 全文大小：295 K

文摘

Alkoxyamino derivatives of oligosaccharides have been synthesized by enzymatic synthesis using a glycosynthase and a transglycosidase. The chemoselective assembly of unprotected oligosaccharides bearing glucose at the reducing end with N-alkyl-O-benzylhydroxylamine provides sugar derivatives that are good acceptors for enzymatic synthesis using either glycosynthase or transglycosidase. Furthermore, this method affords the possibility of controlling the regioselectivity of coupling depending on the nature of the alkoxyamino substituent and provides high-yield coupling of sugars without the need for complex protecting group chemistry.