Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials?
Preclinical studies generally suffer from a lack of consistency and replication.
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Preclinical data is inconclusive regarding optimal cell type/manipulation for clinical trials.
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Use of improper controls and inappropriate statistics prevents interpretation of many studies.
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Future clinical trials should release negative results to the SCI research field.
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