Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation

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• 作者：Emily L. Goldberg¹ ; ² ; Vishwa Deep Dixit¹ ; ² ; ^{Vishwa.Dixit@yale.edu}
• 关键词：Macrophage ; Adipose tissue ; Inflammation ; Carnitine acyltransferase
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：6
• 期：2
• 页码：219-225
• 全文大小：1553 K
• 卷排序：6

文摘

Role of CrAT in macrophage inflammation was tested in vivo. Myeloid CrAT does not regulate inflammation during HFD-induced obesity. Fasting-induced metabolic stress is not regulated by myeloid CrAT expression. CrAT expression in myeloid cells does not regulate LPS-induced acute endotoxemia. Mitochondrial acetyl-CoA efflux via CrAT does not regulate macrophage inflammation.