Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome

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Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome

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作者：Takayasu Mishima^a ; ^b ; ^{mishima1006@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Taizo Ishikawa^a ; ^c ; ^{taizo.ishikawa@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Keiko Imamura^a ; ^{keiko.imamura@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Takayuki Kondo^a ; ^{takayuki.kondo@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yasushi Koshiba^a ; ^d ; ^{ykoshiba@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Ryosuke Takahashi^d ; ^{ryosuket@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Takahashi^a ; ^{jbtaka@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Akihiro Watanabe^e ; ^{watanabe-a@oomuta-h.com" class="auth_mail" title="E-mail the corresponding author} ; Naoki Fujii^e ; ^{fujii@oomuta.hosp.go.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshio Tsuboi^b ; ^{tsuboi@cis.fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Haruhisa Inoue^a ; ^{haruhisa@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：iPSC ; Tyrosine hydroxylase-positive neuron ; Aggregate ; DCTN1 ; Perry syndrome
刊名：Parkinsonism & Related Disorders
出版年：2016
出版时间：September 2016
年：2016
卷：30
期：Complete
页码：67-72
全文大小：1894 K

文摘

•: We describe clinical and neuroimaging investigations of a Perry syndrome patient.
•: We generate induced pluripotent stem cells (iPSCs) from a Perry syndrome patient.
•: Perry syndrome tyrosine hydroxylase-positive neurons show dynactin aggregates in cytoplasm.

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