Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4<sup>DDB2</sup> E3 Ligase

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Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4^DDB2 E3 Ligase

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作者：Yongfei Yang¹ ; Shanshan He¹ ; Qiaoxiu Wang¹ ; Fan Li² ; Mi-Jeong Kwak³ ; Sally Chen¹ ; Douglas O&rsquo ; Connell¹ ; Tian Zhang¹ ; Sara Dolatshahi Pirooz¹ ; YongHeui Jeon¹ ; Nyam-Osor Chimge⁴ ; Baruch Frenkel⁴ ; Younho Choi¹ ; Grace M. Aldrovandi² ; Byung-Ha Oh³ ; Zengqiang Yuan⁵ ; Chengyu Liang¹ ; ^{chengyu.liang@med.usc.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Molecular Cell
出版年：2016
出版时间：19 May 2016
年：2016
卷：62
期：4
页码：507-519
全文大小：4575 K

文摘

•: UVRAG is strictly required for global genomic NER, independently of autophagy
•: UVRAG accumulates at photolesions and associates with DDB1
•: UVRAG expression inversely correlates with UV-like mutagenesis in melanoma
•: UVRAG-DDB1 interaction antagonizes CAND1 and activates CRL4^DDB2 E3 ligase complex

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