Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells

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Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells

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作者：Nam Cong-Nhat Huynh^a ; ^b ; ^e ; Vincent Everts^c ; Akira Nifuji^d ; Prasit Pavasant^a ; ^e ; Ruchanee Salingcarnboriboon Ampornaramveth^f ; ^{ruchanee.a@chula.ac.th} ; ^{ruchanee@gmail.com}
关键词：HAT ; histone acetyltransferase ; HDAC ; Histone deacetylase ; hPDLCs ; human periodontal ligament cells ; PCL/PEG ; polycaprolactone/polyethylene glycol ; TSA ; Trichostatin A
刊名：Bone
出版年：2017
出版时间：February 2017
年：2017
卷：95
期：Complete
页码：76-84
全文大小：1917 K
卷排序：95

文摘

Histone deacetylase inhibitor TSA induces hyper-acetylation of RUNX2. TSA enhances mineral deposition by hPDLCs in in vitro 3D cultures. TSA pre-treated hPDLCs enhances bone regeneration of mouse calvaria defects.