Fasting induces prominent proteomic changes in liver in very long chain Acyl-CoA dehydrogenase deficient mice

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Fasting induces prominent proteomic changes in liver in very long chain Acyl-CoA dehydrogenase deficient mice

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作者：Wei Wang^a ; ^b ; ^{wangwei@shchildren.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Johan Palmfeldt^c ; Al-Walid Mohsen^d ; Niels Gregersen^c ; Jerry Vockley^b ; ^d
关键词：VLCAD deficiency ; β-oxidation ; Oxidative phosphorylation ; Proteomics ; HSP60 ; HSP610
刊名：Biochemistry and Biophysics Reports
出版年：2016
出版时间：December 2016
年：2016
卷：8
期：Complete
页码：333-339
全文大小：1084 K

文摘

•: VLCAD deficient mice show significant changes in the proteome compared to wild type animals.
•: Hypoglycemia induces different proteomic changes in VLCAD deficient mice than is seen in wild type animals.
•: Multiple functional pathways are altered in VLCAD deficient animals.
•: Proteomic changes in VLCAD deficient mice may help understand the physiologic ramifications of this deficiency in humans.

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