Simvastatin induces differentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways

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Simvastatin induces differentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways

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作者：Yohan Han ; Song Ja Kim ; ^{85@kongju.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：HMG-CoA ; hydroxy-methyl-glutaryl Coenzyme A ; ECM ; extracellular matrix ; IHC ; immunohistochemichemistry ; IF ; immunofluorescence ; RT-PCR ; reverse transcription polymerase chain reaction ; OA ; osteoarthritis ; ECM ; extracellular matrix ; PGs ; proteoglycans ; BMP-2 ; bone morphogenetic protein-2 ; MAPKs ; mitogen activated protein kinases ; ERK-1/2 ; extracellular signal-regulated kinase-1/2 ; SB ; SB203580 ; PD ; PD98059 ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; MMP ; matrix metalloproteinase
刊名：Experimental Cell Research
出版年：2016
出版时间：15 August 2016
年：2016
卷：346
期：2
页码：198-205
全文大小：4444 K

文摘

•: Simvastatin induces differentiation of rabbit articular chondrocytes.
•: Simvastatin induced differentiation is regulated by ERK-1/2 and p38 kinase pathways.
•: Simvastatin inhibits de-differentiation in serial monolayer culture.

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