Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

详细信息    查看全文

• 作者：Yang W. Zhang¹ ; Zhihong Wang² ; Wenbing Xie¹ ; Yi Cai¹ ; Limin Xia¹ ; Hariharan Easwaran¹ ; Jianjun Luo¹ ; ⁴ ; Ray-Whay Chiu Yen¹ ; Yana Li³ ; Stephen B. Baylin¹ ; ⁵ ; ^{sbaylin@jhmi.edu}
• 关键词：TET2 ; acetylation ; DNA methylation ; oxidative stress ; 5hmC ; DNA demethylation ; cancer
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：323-335
• 全文大小：4181 K
• 卷排序：65

文摘

TET2 is acetylated at K110 by p300 and deacetylated by HDAC1/2 Acetylation increases TET2 activity, protein stability, and partnering with DNMT1 Oxidative stress targets TET2/DNMTs to chromatin, increases DNAm and 5hmC TET2 KO induces DNA hypermethylation in a manner similar to oxidative stress