Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

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• 作者：Yanxia Guo¹ ; ⁷ ; Kenzie D. MacIsaac² ; ⁸ ; Yi Chen¹ ; Richard J. Miller² ; Renu Jain¹ ; Barbara Joyce-Shaikh¹ ; Heidi Ferguson² ; I-Ming Wang³ ; Razvan Cristescu¹ ; John Mudgett⁴ ; Laura Engstrom² ; Kyle J. Piers² ; Gretchen A. Baltus² ; Kenneth Barr² ; Hongjun Zhang² ; Huseyin Mehmet² ; Laxminarayan G. Hegde² ; Xiao Hu⁵ ; Laura L. Carter⁵ ; Thomas D. Aicher⁵ ; Gary Glick⁵ ; Dennis Zaller² ; Abbas Hawwari⁶ ; Craig C. Correll² ; Dallas C. Jones² ; ⁹ ; Daniel J. Cua¹ ; ¹⁰ ; ^{daniel.cua@merck.com}
• 关键词：RORγT ; small-molecule antagonist ; thymopoiesis ; T cell repertoire ; autoimmunity ; experimental autoimmune encephalomyelitis ; experimental psoriasis
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3206-3218
• 全文大小：4797 K
• 卷排序：17

文摘

RORγ antagonist treatment recapitulates Rorc-deletion-induced DP thymocyte apoptosis RORγ regulates genes that control TCRα selection, thymocyte migration, and apoptosis RORγT inhibition skews TCRα usage and limits T cell repertoire diversity RORγ antagonist reduces MOG-tetramer+ TCR precursor frequency and EAE