Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells

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• 作者：Anna Signorile^a ; ¹ ; ^{anna.signorile@uniba.it} ; Arcangela Santeramo^a ; Grazia Tamma^b ; Tommaso Pellegrino^b ; Susanna D'Oria^c ; Paolo Lattanzio^d ; Domenico De Rasmo^d ; ¹
• 关键词：8-Br-cAMP ; 8-Bromoadenosine 3&prime ; 5&prime ; -cyclic monophosphate ; 8pCPT ; 8-pCPT-2&prime ; -O-Me-cAMP ; cAMP ; 3&prime ; 5&prime ; -cyclic adenosine monophosphate ; DRP-1 ; Dynamin related protein 1 ; Epac ; exchange protein directly activated by cAMP ; L-OPA ; long OPA1 ; OPA1 ; optic atrophy 1 ; PKA ; protein kinase A ; ROS ; reactive oxygen species ; sAC ; soluble adenylyl cyclase ; S-OPA ; short OPA1 ; t-BHP ; tert-butyl hydroperoxide ; tmAC ; transmembrane adenylyl cyclase
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：355-366
• 全文大小：2394 K
• 卷排序：1864

文摘

Mitochondrial cAMP is reduced in ROS-dependent apoptosis. 8-Br-cAMP prevents ROS-induced apoptosis in rat cardiomyoblasts. Mitochondrial cAMP/PKA signal controls Sirt3 level and OPA1 proteolytic processing. Mitochondrial cAMP/sirt3/OPA1 network in apoptosis.