Inhibitors of mycobacterial Enoyl ACP reductase were designed using in silico approach.

Synthesis of a range of these pyrrolyl chalcones, pyrazoles, isoxazoles and phenyl thiourea derivatives is described.

20">Surflex docking studies were carried out to understand the binding affinity of the compounds.

25">Inhibitors were active against Mycobacterium tuberculosis, Staphylococcus aureus, Eschrichia coli, Cell-line (A549) and InhA.