Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

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Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

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作者：Sunil Singhal¹ ; ⁵ ; Pratik S. Bhojnagarwala¹ ; Shaun O'Brien² ; Edmund K. Moon² ; Alfred L. Garfall³ ; Abhishek S. Rao¹ ; Jon G. Quatromoni¹ ; Tom Li Stephen⁶ ; Leslie Litzky⁴ ; Charuhas Deshpande⁴ ; Michael D. Feldman⁴ ; Wayne W. Hancock⁴ ; ⁷ ; Jose R. Conejo-Garcia⁶ ; Steven M. Albelda² ; Evgeniy B. Eruslanov¹ ; ^{evgeniy.eruslanov@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cancer Cell
出版年：2016
出版时间：11 July 2016
年：2016
卷：30
期：1
页码：120-135
全文大小：4958 K

文摘

•: Lung tumors accumulate a subset of TANs with a granulocyte and APC hybrid phenotype
•: APC-like hybrid neutrophils are able to stimulate the anti-tumor T cell responses
•: IFN-γ and GM-CSF are requisite factors for the development of hybrid neutrophils
•: Ikaros negatively regulates the development of hybrid neutrophils from progenitors

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