The effect of 17α-ethynylestradiol induced intrahepatic cholestasis of pregnancy on placental P-glycoprotein in mice: Implications in the individualized transplacental digoxin treatment for fetal heart failure

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The effect of 17α-ethynylestradiol induced intrahepatic cholestasis of pregnancy on placental P-glycoprotein in mice: Implications in the individualized transplacental digoxin treatment for fetal heart failure

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作者：Chuan Wang^a ; ^b ; ^d ; Yi Zhang^b ; ^e ; Yalan Zhan^a ; ^b ; ^d ; Chunyan Luo^d ; Yifei Li^a ; ^b ; Dajian Qiu^b ; ^e ; Dezhi Mu^c ; ^e ; Hongyu Duan^a ; ^b ; Kaiyu Zhou^a ; ^b ; ^e ; ^{kaiyuzhou313@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yimin Hua^a ; ^b ; ^e ; ^{nathan_hua@126.com" class="auth_mail" title="E-mail the corresponding author} ; ^{nathan_hua@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Intrahepatic cholestasis of pregnancy ; Placenta ; P-glycoprotein ; HIF-1α ; Digoxin ; Fetal heart failure
刊名：Placenta
出版年：2016
出版时间：August 2016
年：2016
卷：44
期：Complete
页码：91-97
全文大小：1341 K

文摘

•: ICP up-regulated placental P-gp expression in mice.
•: ICP reduced transplacental digoxin transfer rate in mice.
•: Up-regulation of placental HIF-1α might contribute to elevation of P-gp expression.
•: The findings may be of relevance to individualized transplacental digoxin treatment for fetal heart failure.